This first-in-class medicine has since been approved in the EU and Canada and is driving positive share trends in earlier therapy lines in the US. We are confident DARZALEX can become the standard of care in multiple myeloma and help even more than the 10,000 patients who have benefited already worldwide. Growth will continue to accelerate with the anticipated approval in second line patient populations and the impressive data from the recently published CASTOR and POLLUX studies. An additional five Phase 3 trials are currently under way, as well as development of a subcutaneous formulation. As Bill will detail, we have also seen positive data that DARZALEX may be effective outside of multiple myeloma. What should be clear today is that all of our current market-leading medicines have significant potential for continued volume growth. Additionally, we have a multitude of promising potential line extensions across every therapeutic area, approximately 40 in total by 2019. Of these, 10 have more than $0.5 billion potential. The remaining 30 potential line extensions are not insignificant. Cumulatively, the line extensions for XARELTO and INVOKANA have the potential to drive $3 million to $5 million in incremental sales for the Cardiovascular franchise.

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However, there can be injuries that are more severe, such as high ankle sprains, which can be more difficult to treat and could require surgery. The article will help prevent the... The injured leg is wrapped in a cast and is kept in an elevated position, while lying down, above the level of the heart. their websiteSwollen feet and ankles is a common problem faced by many elderly people. Tendinitis can be caused if there is excess stress applied to the ankle or even if there is repetitive strain on an injured ankle, like in a sport. Ankle pain and swelling can be caused by various medical conditions that can range from an infection through an open wound, an early symptom of diabetes, to water-retention. Along with making your body flexible and muscles stronger, yoga relaxes you and makes you calm. Treatment for ankle pain mainly involves simple home care and remedies.

Ankle Pain

It almost feels like I have a splinter in there.I have inspected the area and can find no evidence of any cut or foreign object. This can give an electric shock-like sharp brief pain.It is most likely that whatever the cause, this is a self-limiting condition that will settle down in due course.Give it some rest, perhaps take some anti-inflammatories like ibuprofen if you have no contraindications to them, and give it a bit of time.Clearly, if things do not improve, then you will need to go and tell your doctor about it for some further advice.Yours sincerelyThe NetDoctor Medical TeamOther Qs & AsBunionsCramps on toes and feetFallen archesFlat feet worryHeel spurHeel spursHow can I stop my feet from swelling?Recommended When it becomes inflamed it is called plantar fasciitis.This is more usually felt at the point where the fascia is attached to the heel bone, so is felt more under the heel than in the middle of the foot.This is typically worse when you first get up in the mornings, and eases off a bit if you walk about. Also, feeling the area, there is no swelling or anything of the sort.Advertisement - Continue Reading BelowThe only evident of something being wrong is the slight pain I experience from time to time. What's causing painful feet?On the sole of my right foot where there is a muscle connecting the ball to the heel, I feel a sharp pain from time to time when I walk or run. I am only 20 and have a bunionI have bony lumps forming on my feetI sprained my ankle but want to keep fitI stubbed my big toe playing footballI suffer from goutI twisted my ankle and fell onto my kneecapI want to strengthen the ligaments in my ankleI went over my ankleI went over my ankle while runningMy baby has crossed toesMy daughter has been suffering with heat in her toesMy three-year-old always walks on tiptoesPain around the heelPain in the footPain in the heelsPain on my left anklePainful Achilles tendonPainful bunionPainful heelsSprained ankleSuffering from inflamed tendonsTwisted ankleUnburden my solesWhat are rocker bottom feet?I expected the sporadic pain to go away, but while it's hard to say if it is getting worse, it certainly isn't getting any better.AnswerThis problem is one of those where it is easiest if you can see exactly where the pain is being felt, so it's hard to be precise.What you are calling a muscle is actually a band of tough ligamentous tissue called fascia, in this case the plantar fascia, meaning it is in the underside of the foot. Why do my ankles swell even when I am inactive?

Boxers and Spaniels are susceptible to dodgy hearts, Labrador and Golden Retrievers are prone to progressive retinal atrophy, Setters' can get canine leukocyte adhesion deficiency and Alsations, hip dysplasia. Septic arthritis normally only affects a single joint and the condition results in swelling, fever, heat, and pain in the joint. Bacteria is one of the most common causes of infective arthritis in dogs. In the case of the knee there are typically four parts: Femoral component. Against this backdrop, pet insurance is now the fastest growing form of insurance in the UK. It develops in various joints in the human body and in some people it particularly affects the large weight-bearing joints of the hip and the knee. Diagnosis of septic arthritis was confirmed by physical and orthopaedic examinations, evaluation of radiography and synovial fluid analysis including leukocyte and neutrophil counts, cytological examination and bacterial culture. Septic Arthritis in other terms as Bacterial Arthritis or Infectious Arthritis is an infection in the fluid and tissues of joint cavity most commonly caused by bacteria. Your cat may have nine lives but you may well land yourself with nine vets' bills! If so, what is it?